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KMID : 1007520140230041313
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Food Science and Biotechnology
2014 Volume.23 No. 4 p.1313 ~ p.1319
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Cyanidin-3-glucoside Ameliorates CCl4-induced Liver Injury in Mice
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Cho Byoung-Ok
Lee Chang-Wook
So Yang-kang
Jin Chang-Hyun
Kang Si-Yong
Kim Dong-Sub
Seo Kwon-Il
Yook Hong-Sun
Jeong Il-Yun
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Abstract
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The protective effect of cyanidin-3-glucoside (C3G) against carbon tetrachloride (CCl4)-induced liver injury in mice was investigated. Administration of C3G attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in CCl4-treated mice. Histopathological examination of mouse livers showed that C3G reduced the incidence of liver lesions induced by CCl4. Moreover, C3G prevented DNA damage and decreased the protein levels of γ-H2AX in CCl4-treated mouse livers. C3G also increased the activity of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, which were decreased due to CCl4 administration in CCl4-treated mouse livers. C3G inhibited the expression levels of IL-6 and iNOS in CCl4-treated mice. C3G apparently protects the liver from CCl4-induced hepatic damage through antioxidant and anti-inflammatory mechanisms.
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KEYWORD
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carbon tetrachloride, cyanidin-3-glucoside, lipid peroxidation, liver injury
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